3-oxoacyl-[acyl-carrier-protein] synthase 1

3-oxoacyl-[acyl-carrier-protein] synthase 1 is an essential condensing enzyme in the type II fatty acid synthesis pathway. It catalyzes the addition of malonyl-ACP to an acyl-ACP, elongating the fatty acid chain by two carbons. It functions as a homodimer or tetramer and contains a catalytic cysteine residue. The enzyme is a validated antibacterial drug target; inhibitors of this enzyme block the biosynthesis of long-chain fatty acids, halting bacterial growth. Its homologs are also present in mitochondria, where they participate in fatty acid chain elongation mechanisms[6][7]. If further specificity is needed (e.g., specifying the organism or distinguishing among multiple isoforms such as KAS I, II, or III), consult the relevant UniProt or NCBI entry for sequence, structure, and organism context[6][7].

Other names

3-oxoacyl-[acyl-carrier-protein] synthase IKAS IFabBbeta-ketoacyl-ACP synthase Ibeta-ketoacyl-acyl carrier protein synthase 1

Inhibition of the condensation step in fatty acid synthesis, blocking cell membrane formation in bacteria[6]